Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca entry in human pulmonary arterial smooth muscle cells
نویسندگان
چکیده
Hisao Yamamura, Aya Yamamura, Eun A. Ko, Nicole M. Pohl, Kimberly A. Smith, Amy Zeifman, Frank L. Powell, Patricia A. Thistlethwaite, and Jason X.-J. Yuan Department of Medicine, Institute for Personalized Respiratory Medicine, Department of Pharmacology; Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois; Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; School of Pharmacy, Kinjo Gakuin University, Nagoya, Japan; and Departments of Medicine and Surgery, University of California, San Diego, La Jolla, California
منابع مشابه
Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells.
Notch signaling plays a critical role in controlling proliferation and differentiation of pulmonary arterial smooth muscle cells (PASMC). Upregulated Notch ligands and Notch3 receptors in PASMC have been reported to promote the development of pulmonary vascular remodeling in patients with pulmonary arterial hypertension (PAH) and in animals with experimental pulmonary hypertension. Activation o...
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Platelet-derived growth factor (PDGF) and its receptor are known to be substantially elevated in lung tissues and pulmonary arterial smooth muscle cells (PASMC) isolated from patients and animals with pulmonary arterial hypertension. PDGF has been shown to phosphorylate and activate Akt and mammalian target of rapamycin (mTOR) in PASMC. In this study, we investigated the role of PDGF-mediated a...
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Lu W, Ran P, Zhang D, Lai N, Zhong N, Wang J. Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca entry, and basal [Ca ]i in rat distal pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol 299: C1370–C1378, 2010. First published September 15, 2010; doi:10.1152/ajpcell.00040.2010.—Recent advances have identified an important rol...
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Recent advances have identified an important role of bone morphogenetic protein 4 (BMP4) in pulmonary vascular remodeling, yet the underlying mechanisms remain largely unexplored. We have previously found that Ca(2+) influx through store-operated calcium channels (SOCC), which are mainly thought to be composed of canonical transient receptor potential (TRPC) proteins, likely contribute to the p...
متن کاملASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry.
Acid-sensing ion channels (ASIC) are voltage-insensitive, cationic channels that have recently been identified in vascular smooth muscle (VSM). It is possible that ASIC contribute to vascular reactivity via Na(+) and Ca(2+) conductance; however, their function in VSM is largely unknown. In pulmonary VSM, store-operated Ca(2+) entry (SOCE) plays a significant role in vasoregulatory mechanisms su...
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تاریخ انتشار 2014